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Characteristics of Lynch Syndrome
Diagnosis and Management
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LYNCH SYNDROME MUTATED GENES

 

Lynch syndrome cancers are caused by mutations in seven mismatch repair genes, specifically:

 

MSH2 2p16 chromosome 45-50%


MLH1 3p22.3/A> chromosome 20%


MSH6 2p16 chromosome 10%


PMS2 7P22.1 chromosome 1%

 

EPCAM


PMS1 2Q32.2 chromosome Rare


MSH3 5q14.1 chromosome Rare


EXO1 1q1q43 chromosome Rare

 

Other Genes Not Yet Discovered 20-25% prev

 

 



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